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Aging through the lens of mitochondrial DNA mutations and inheritance paradoxes.

Biogerontology - 27 Dec 2024

Chen Jia, Li Hongyu, Liang Runyu, Huang Yongyin, Tang Qiang

Abstract excerpt

Mitochondrial DNA encodes essential components of the respiratory chain complexes, serving as the foundation of mitochondrial respiratory function. Mutations in mtDNA primarily impair energy metabolism, exerting far-reaching effects on cellular physiology, particularly in the context of aging. The intrinsic vulnerability of mtDNA is increasingly recognized as a key driver in the initiation of aging and the...

Topics

DNA, Mitochondrial
Humans
Aging
Mutation
Animals
Mitochondria
Oxidative Stress
Cellular Senescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39729246
DOI: 10.1007/s10522-024-10175-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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