Article
Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment.
Proceedings of the National Academy of Sciences of the United States of America - 21 Dec 2004
Zhao Yong, Scheuer Todd, Catterall William A
Abstract excerpt
Members of the voltage-gated-like ion channel superfamily have a conserved pore structure. Transmembrane helices that line the pore (M2 or S6) are thought to gate it at the cytoplasmic end by bending at a hinge glycine residue. Proline residues favor bending of alpha-helices, and substitution of proline for this glycine (G219) dramatically stabilizes the open state of a bacterial Na(+) channel NaChBac. Here we...
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