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Article

Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties.

Channels (Austin, Tex.) - 1 Jan 2000

Imbrici Paola, Grottesi Alessandro, D'Adamo Maria Cristina, Mannucci Roberta, Tucker Stephen J, Pessia Mauro

Abstract excerpt

Shaker-like (KV1.1) channels contain a highly conserved Pro-Val-Pro (PVP) motif at the base of S6 that produces a kink in the S6 helices and provides a flexible element thought to be essential for channel gating. The role of proline-induced kinks in transmembrane helices is well known, but the contribution of the small hydrophobic valine between these two prolines is not known, and interestingly, Shab-like...

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Identifiers

PMID: 19202350
DOI: 10.4161/chan.3.1.7548

Genes

PIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties.PMID 19202350Read ↗

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