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Article

A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics.

American journal of physiology. Cell physiology - 1 Jun 2008

Labro Alain J, Grottesi Alessandro, Sansom Mark S P, Raes Adam L, Snyders Dirk J

Abstract excerpt

The Kv1-4 families of K+ channels contain a tandem proline motif (PXP) in the S6 helix that is crucial for channel gating. In human Kv1.5, replacing the first proline by an alanine resulted in a nonfunctional channel. This mutant was rescued by introducing another proline at a nearby position, ch...

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Identifiers

PMID: 18385285
DOI: 10.1152/ajpcell.00479.2007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18385285-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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