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Article

Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life.

Neurobiology of aging - 1 Feb 2005

Almeida Osvaldo P, Flicker Leon, Lautenschlager Nicola T, Leedman Peter, Vasikaran Samuel, van Bockxmeer Frank M

Abstract excerpt

Homocysteine (Hcy) is harmful to neurons and blood vessels, including the cerebral microvasculature. It is possible that such effects contribute to the cascade of events that leads to cognitive decline, dementia, and depression in later life. Hcy is produced during the metabolism of the essential amino-acid methionine, which also involves a methyl group transfer derived from folate and choline metabolism. Its...

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Source

Identifiers

PMID: 15582752
DOI: 10.1016/j.neurobiolaging.2004.03.007

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life.PMID 15582752Read ↗

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