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Article

Biological and clinical implications of the MTHFR C677T polymorphism.

Trends in pharmacological sciences - 1 Apr 2001

Ueland P M, Hustad S, Schneede J, Refsum H, Vollset S E

Abstract excerpt

The enzyme methylenetetrahydrofolate reductase (MTHFR) directs folate species either to DNA synthesis or to homocysteine (Hcy) remethylation. The common MTHFR C677T polymorphism affects the activity of the enzyme and hence folate distribution. Under conditions of impaired folate status, the homozygous TT genotype has been regarded as harmful because it is associated with a high concentration of plasma total Hcy,...

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Source

Identifiers

PMID: 11282420
DOI: 10.1016/s0165-6147(00)01675-8

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Biological and clinical implications of the MTHFR C677T polymorphism.PMID 11282420Read ↗

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