Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and cognitive impairment: the health in men study.

Molecular psychiatry - 1 May 2012

Ford A H, Flicker L, Hankey G J, Norman P, van Bockxmeer F M, Almeida O P

Abstract excerpt

High total plasma homocysteine (tHcy) has been associated with cognitive impairment in later life, but it is unclear if this association is causal or is due to confounding. The C677T polymorphism of the 5,10 methylenetetrahydrofolate reductase gene (MTHFR) increases basal tHcy, but its contribution to cognitive impairment has not been established. We designed this study to determine if tHcy is causally related to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Aging
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cognition Disorders

Share to Homocysteine

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Odds Ratio

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 21358708
DOI: 10.1038/mp.2011.18
PMCID: PMC3335075

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and cognitive impairment: the health in men study.PMID 21358708Read ↗

Plasma homocysteine and MTHFRC677T polymorphism as risk factors for incident dementia.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase 677C>T and methionine synthase 2756A>G mutations: no impact on survival, cognitive functioning, or cognitive decline in nonagenarians.Semantic proximity Read ↗

Polymorphism of MTHFR C677T, serum vitamin levels and cognition in subjects with hyperhomocysteinemia in China.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T polymorphism and cognitive function in older women.Semantic proximity Read ↗

Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life.Semantic proximity Read ↗

High homocysteine and epistasis between MTHFR and APOE: association with cognitive performance in the elderly.Semantic proximity Read ↗

Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85.Semantic proximity Read ↗

Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Alzheimer Disease Risk: a Meta-Analysis.Semantic proximity Read ↗

Homocysteine and cognitive function in elderly people.Semantic proximity Read ↗

Folate Pathway Gene Methylenetetrahydrofolate Reductase C677T Polymorphism and Alzheimer Disease Risk in Asian PopulationSemantic proximity Read ↗

Epigenetic Factors in Late-Onset Alzheimer’s Disease: MTHFR and CTH Gene Polymorphisms, Metabolic Transsulfuration and Methylation Pathways, and B VitaminsSemantic proximity Read ↗

The C677T variant in MTHFR modulates associations between blood-based and cerebrospinal fluid biomarkers of neurodegeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.