Article
MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults.
International journal of epidemiology - 25 Dec 2023
Bennett Derrick A, Parish Sarah, Millwood Iona Y, Guo Yu, Chen Yiping, Turnbull Iain, Yang Ling, Lv Jun, Yu Canqing, Davey Smith George, Wang Yongjun, Wang Yilong, Peto Richard, Collins Rory, Walters Robin G, Li Liming, Chen Zhengming, Clarke Robert
Abstract excerpt
BACKGROUND: The relevance of folic acid for stroke prevention in low-folate populations such as in China is uncertain. Genetic studies of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, which increases plasma homocysteine (tHcy) levels, could clarify the causal relevance of elevated tHcy levels for stroke, ischaemic heart disease (IHD) and other diseases in populations without folic acid...
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