Association of MTHFR C677T polymorphism with loneliness but not depression in cognitively normal elderly males.

doi:10.1016/j.neulet.2012.05.065

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Article

Association of MTHFR C677T polymorphism with loneliness but not depression in cognitively normal elderly males.

Neuroscience letters - 11 Jul 2012

Lan Wen-Hsuan, Yang Albert C, Hwang Jen-Ping, Hong Chen-Jee, Liou Ying-Jay, Yeh Heng-Liang, Liu Mu-En, Tsai Shih-Jen

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is involved in folate and homocysteine metabolism, and has been associated with geriatric disorders, including dementia and late-life depression. The present work aimed to investigate the effect of MTHFR C677T polymorphism on the pres...

Topics

Aged, 80 and over
Cognition
Depression
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Loneliness
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 22668858
DOI: 10.1016/j.neulet.2012.05.065

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-22668858-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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