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Article

Association of MTHFR C677T polymorphism with loneliness but not depression in cognitively normal elderly males.

Neuroscience letters - 11 Jul 2012

Lan Wen-Hsuan, Yang Albert C, Hwang Jen-Ping, Hong Chen-Jee, Liou Ying-Jay, Yeh Heng-Liang, Liu Mu-En, Tsai Shih-Jen

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is involved in folate and homocysteine metabolism, and has been associated with geriatric disorders, including dementia and late-life depression. The present work aimed to investigate the effect of MTHFR C677T polymorphism on the presence of depression and loneliness in cognitively normal male subjects. A total of 323 cognitively normal male subjects...

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Source

Identifiers

PMID: 22668858
DOI: 10.1016/j.neulet.2012.05.065

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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