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Article

Plasma homocysteine and MTHFRC677T polymorphism as risk factors for incident dementia.

Journal of neurology, neurosurgery, and psychiatry - 1 Jan 2012

Ford Andrew H, Flicker Leon, Alfonso Helman, Hankey Graeme J, Norman Paul E, van Bockxmeer Frank M, Almeida Osvaldo P

Abstract excerpt

BACKGROUND: Elevated total plasma homocysteine (tHcy) has been associated with increased risk of dementia. The C677T polymorphism of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) increases tHcy and provides a means of studying the association between tHcy and dementia while not being as susceptible to the common biases and confounding of observational studies. The authors designed this longitudinal...

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Identifiers

PMID: 21746742
DOI: 10.1136/jnnp.2011.242446

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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