Article
Age and gender affect the relation between methylenetetrahydrofolate reductase C677T genotype and fasting plasma homocysteine concentrations in the Framingham Offspring Study Cohort.
The Journal of nutrition - 1 Nov 2003
Russo Giuseppina T, Friso Simonetta, Jacques Paul F, Rogers Gail, Cucinotta Domenico, Wilson Peter W F, Ordovas Jose M, Rosenberg Irwin H, Selhub Jacob
Abstract excerpt
The C677T variant of methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the remethylation of homocysteine to methionine, is a frequent genetic cause of mild hyperhomocysteinemia among individuals with low folate status. However, little is known about the influence of subject characteristics, such as age and sex, on the relation between the C677T MTHFR polymorphism and fasting plasma total homocysteine...
Topics
- Adult
- Age Factors
- Analysis of Variance
- Cohort Studies
- Female
- Genotype
- Homocysteine
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)