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Article

The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis.

Molecular psychiatry - 1 Apr 2006

Lewis S J, Lawlor D A, Davey Smith G, Araya R, Timpson N, Day I N M, Ebrahim S

Abstract excerpt

Low dietary folate intake has been implicated as a risk factor for depression. However, observational epidemiological studies are plagued by problems of confounding, reverse causality and measurement error. A common polymorphism (C677T) in MTHFR is associated with methyltetrahydrofolate reductase (MTHFR) activity and circulating folate and homocysteine levels and offers insights into whether the association...

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Source

Identifiers

PMID: 16402130
DOI: 10.1038/sj.mp.4001790

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis.PMID 16402130Read ↗

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