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Methylenetetrahydrofolate reductase and psychiatric diseases

5 Nov 2018

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for the critical process of one-carbon metabolism involving folate and homocysteine metabolisms. It is known that some polymorphism of MTHFR would result in reduction of MTHFR enzyme activity as well as DNA methylation process, later shown to have significant impacts in various psychiatric diseases. However, it is unclear whether the polymorphism of...

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PMID: 30397195
DOI: 10.1038/s41398-018-0276-6

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