Article
Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways.
Experimental gerontology - 1 Jan 2000
Kojima Toshio, Kamei Hidehiko, Aizu Tomoyuki, Arai Yasumichi, Takayama Michiyo, Nakazawa Susumu, Ebihara Yoshinori, Inagaki Hiroki, Masui Yukie, Gondo Yasuyuki, Sakaki Yoshiyuki, Hirose Nobuyoshi
Abstract excerpt
Recent studies have demonstrated a significant association between mutations in genes involved in the insulin/IGF1 signaling pathway and extension of the life span of model organisms. In this study which compared 122 Japanese semisupercentenarians (older than 105) with 122 healthy younger controls, we examined polymorphic variations of six genes which are involved in insulin/IGF1 signaling. These genes were...
Topics
- Adult
- Aged
- Aged, 80 and over
- Case-Control Studies
- Female
- Haplotypes
- Humans
- Insulin
- Insulin-Like Growth Factor I
- Japan
- Linkage Disequilibrium
- Longevity
- Male