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Article

Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Mar 2014

Morris Brian J, Donlon Timothy A, He Qimei, Grove John S, Masaki Kamal H, Elliott Ayako, Willcox D Craig, Willcox Bradley J

Abstract excerpt

Evidence from model organisms suggests that the insulin/IGF-1 signaling pathway has an important, evolutionarily conserved influence over rate of aging and thus longevity. In humans, the FOXO3 gene is the only widely replicated insulin/IGF-1 signaling pathway gene associated with longevity across multiple populations. Therefore, we conducted a nested case-control study of other insulin/IGF-1 signaling genes and...

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Source

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Identifiers

PMID: 23770741
DOI: 10.1093/gerona/glt082
PMCID: PMC3968832

Genes

FOXO3
ATF4
CBL
EXO1
JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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