Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The identities of sym-2, sym-3 and sym-4, three genes that are synthetically lethal with mec-8 in Caenorhabditis elegans.

Genetics - 1 Nov 2004

Yochem John, Bell Leslie R, Herman Robert K

Abstract excerpt

On the basis of synthetic lethality, five genes in Caenorhabditis elegans are known to be redundant with the mec-8 gene, which encodes a protein that contains two copies of an RNA recognition motif (RRM) and affects alternative RNA splicing. The molecular identities of two of the redundant genes, sym-1 and sym-5, were previously reported. The remaining three genes have now been cloned, and their synthetically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Lethal

Share to Molecular Sequence Data

Share to Phenotype

Share to RNA-Binding Proteins

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 15579686
DOI: 10.1534/genetics.104.029827
PMCID: PMC1448807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The identities of sym-2, sym-3 and sym-4, three genes that are synthetically lethal with mec-8 in Caenorhabditis elegans.PMID 15579686Read ↗

Functional overlap between the mec-8 gene and five sym genes in Caenorhabditis elegans.Semantic proximity Read ↗

The SL1 trans-spliced leader RNA performs an essential embryonic function in Caenorhabditis elegans that can also be supplied by SL2 RNA.Semantic proximity Read ↗

Identification of essential genes in Caenorhabditis elegans through whole-genome sequencing of legacy mutant collections.Semantic proximity Read ↗

An emerging model organism Caenorhabditis elegans for alternative pre-mRNA processing in vivo.Semantic proximity Read ↗

CRISPR-mediated genetic interaction profiling identifies RNA binding proteins controlling metazoan fitness.Semantic proximity Read ↗

Analysis of smu-1, a gene that regulates the alternative splicing of unc-52 pre-mRNA in Caenorhabditis elegans.Semantic proximity Read ↗

High-throughput capturing and characterization of mutations in essential genes of Caenorhabditis elegans.Semantic proximity Read ↗

The mec-8 gene of C. elegans encodes a protein with two RNA recognition motifs and regulates alternative splicing of unc-52 transcripts.Semantic proximity Read ↗

Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions.Semantic proximity Read ↗

Identification of essential genes in <i>Caenorhabditis elegans</i> through whole genome sequencing of legacy mutant collectionsSemantic proximity Read ↗

A genetic mosaic screen of essential zygotic genes in Caenorhabditis elegans.Semantic proximity Read ↗

Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.