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Article

Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions.

Genome biology - 1 Jan 2005

Baugh L Ryan, Wen Joanne C, Hill Andrew A, Slonim Donna K, Brown Eugene L, Hunter Craig P

Abstract excerpt

Phenotypic robustness is evidenced when single-gene mutations do not result in an obvious phenotype. It has been suggested that such phenotypic stability results from 'buffering' activities of homologous genes as well as non-homologous genes acting in parallel pathways. One approach to characterizing mechanisms of phenotypic robustness is to identify genetic interactions, specifically, double mutants where...

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Identifiers

PMID: 15892873
DOI: 10.1186/gb-2005-6-5-r45
PMCID: PMC1175957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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