Article
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.
Nature - 25 Sept 2008
Fischer Sylvia E J, Butler Maurice D, Pan Qi, Ruvkun Gary
Abstract excerpt
Mutations that enhance the response to double-stranded RNA (dsRNA) have revealed components of the RNA interference (RNAi) pathway or related small RNA pathways. To explore these small RNA pathways, we screened for Caenorhabditis elegans mutants displaying an enhanced response to exogenous dsRNAs. Here we describe the isolation of mutations in two adjacent, divergently transcribed open reading frames (eri-6 and...
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