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Article

Functional overlap between the mec-8 gene and five sym genes in Caenorhabditis elegans.

Genetics - 1 Sept 1999

Davies A G, Spike C A, Shaw J E, Herman R K

Abstract excerpt

Earlier work showed that the Caenorhabditis elegans gene mec-8 encodes a regulator of alternative RNA splicing and that mec-8 null mutants have defects in sensory neurons and body muscle attachment but are generally viable and fertile. We have used a genetic screen to identify five mutations in four genes, sym-1-sym-4, that are synthetically lethal with mec-8 loss-of-function mutations. The phenotypes of sym...

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Identifiers

PMID: 10471705
DOI: 10.1093/genetics/153.1.117
PMCID: PMC1460726

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