The SL1 trans-spliced leader RNA performs an essential embryonic function in Caenorhabditis elegans that can also be supplied by SL2 RNA.

doi:10.1101/gad.10.12.1543

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Article

The SL1 trans-spliced leader RNA performs an essential embryonic function in Caenorhabditis elegans that can also be supplied by SL2 RNA.

Genes & development - 15 Jun 1996

Ferguson K C, Heid P J, Rothman J H

Abstract excerpt

Covalent joining of leader RNA exons to pre-mRNAs by trans-splicing has been observed in protists and invertebrates, and can occur in cultured mammalian cells. In the nematode Caenorhabditis elegans, approximately 60% of mRNA species are trans-spliced to the 22-nucleotide SL1 leader, and another...

Topics

Alternative Splicing
Animals
Autoantigens
Base Sequence
Binding Sites
Caenorhabditis elegans
DNA-Binding Proteins
Embryo, Nonmammalian
Genes, Helminth
Genes, Lethal
Molecular Sequence Data
Multigene Family

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Pol1 Transcription Initiation Complex Proteins

RNA

RNA Splicing

Ribonucleoproteins, Small Nuclear

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 8666237
DOI: 10.1101/gad.10.12.1543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8666237-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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