Article
Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice.
The American journal of pathology - 1 Dec 2004
Elhage Rima, Gourdy Pierre, Brouchet Laurent, Jawien Jacek, Fouque Marie-José, Fiévet Catherine, Huc Xavier, Barreira Yara, Couloumiers Jean Claude, Arnal Jean-François, Bayard Francis
Abstract excerpt
Recent studies have demonstrated the importance of lymphocytes, especially CD4(+) T cells, in early lesions of atherosclerosis in hypercholesterolemic mice. However, the role of other T cell subpopulations, like CD8(+) T cells or TCR gamma delta T lymphocytes, is not yet clear. We have therefore generated apolipoprotein E-deficient mice genetically deficient in specific T lymphocyte subpopulations and measured...
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