Article

Lymphocytes are important in early atherosclerosis

2001-07-15

Abstract excerpt

Lymphocytes represent a potentially important proinflammatory cell that localizes to atherosclerotic lesions. To determine whether they contribute to lesion development, atherosclerosis-prone (LDLR–/–) mice were crossed with lymphocyte-deficient (RAG1–/–) mice to generate double knockout progeny. After 8 weeks on a Western-type diet (WTD), lesion development was reduced by 54% in double knockout mice, as compared...

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Literature Corpus work: 4d5851b2-eac3-517c-9981-b37ddc879df2
DOI: 10.1172/jci200111380

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