Article
T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia.
Circulation - 29 May 2001
Huber S A, Sakkinen P, David C, Newell M K, Tracy R P
Abstract excerpt
BACKGROUND: T cells are implicated in atherosclerosis, but little is known about the genetic control or molecular pathways, especially under conditions of mild hypercholesterolemia. METHODS AND RESULTS: BALB/c mice, making a CD4+ Th2 (IL-4+) cell response, express both MHC class II antigens (IA(d), IE(d)) and are atherosclerosis-resistant. C57Bl/6 mice produce a CD4+ Th1 (interferon [IFN]gamma+) response, express...
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