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Article

Cardiac and vascular phenotypes in the apolipoprotein E-deficient mouse

1 Jan 2012

Abstract excerpt

Cardiovascular death is frequently associated with atherosclerosis, a chronic multifactorial disease and a leading cause of death worldwide. Genetically engineered mouse models have proven useful for the study of the mechanisms underlying cardiovascular diseases. The apolipoprotein E-deficient mouse has been the most widely used animal model of atherosclerosis because it rapidly develops severe...

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PMID: 22330242
DOI: 10.1186/1423-0127-19-22

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