Article
New CCR5 variants associated with reduced HIV coreceptor function in southeast Asia.
AIDS (London, England) - 19 Nov 2004
Capoulade-Métay Corinne, Ma Liying, Truong Lien X, Dudoit Yasmine, Versmisse Pierre, Nguyen Ngai V, Nguyen Marie, Scott-Algara Daniel, Barré-Sinoussi Françoise, Debré Patrice, Bismuth Georges, Pancino Gianfranco, Theodorou Ioannis
Abstract excerpt
BACKGROUND: Despite multiple exposure to HIV-1, some individuals remain uninfected. This resistance has been associated with homozygosity for a 32 base pair deletion in the gene for the CCR5 receptor. This variant occurs frequently in Caucasians but is extremely rare in Asians or Africans. OBJECTIVE: To identify variations in CCR5 receptor gene that affect susceptibility to HIV infection in non-Caucasians....
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