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Article

Variants of CCR5, which are permissive for HIV-1 infection, show distinct functional responses to CCL3, CCL4 and CCL5.

Genes and immunity - 1 Oct 2005

Dong H-F, Wigmore K, Carrington M N, Dean M, Turpin J A, Howard O M Z

Abstract excerpt

CCR5 is one of the primary coreceptors for Env-mediated fusion between cells and human immunodeficiency virus type 1 (HIV-1). Analyses of CCR5 variants in cohorts of HIV-1 high-risk individuals led to the identification of multiple single amino-acid substitutions, which may have functional conseq...

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Source

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Identifiers

PMID: 16015368
DOI: 10.1038/sj.gene.6364247
PMCID: PMC1369982

Genes

CCR5
CCL4
CCL5
CCL3
MIP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16015368-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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