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Article

Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity.

Development (Cambridge, England) - 1 Jan 2005

Horsford D Jonathan, Nguyen Minh-Thanh T, Sellar Grant C, Kothary Rashmi, Arnheiter Heinz, McInnes Roderick R

Abstract excerpt

During vertebrate eye development, the cells of the optic vesicle (OV) become either neuroretinal progenitors expressing the transcription factor Chx10, or retinal pigment epithelium (RPE) progenitors expressing the transcription factor Mitf. Chx10 mutations lead to microphthalmia and impaired neuroretinal proliferation. Mitf mutants have a dorsal RPE-to-neuroretinal phenotypic transformation, indicating that...

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Identifiers

PMID: 15576400
DOI: 10.1242/dev.01571

Genes

RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity.PMID 15576400Read ↗

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Chx10 functions as a regulator of molecular pathways controlling the regional identity in the primordial retina.Semantic proximity Read ↗

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chokh/rx3 specifies the retinal pigment epithelium fate independently of eye morphogenesis.Semantic proximity Read ↗

LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis.Semantic proximity Read ↗

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Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation.Semantic proximity Read ↗

Vax1/2 genes counteract Mitf-induced respecification of the retinal pigment epithelium.Semantic proximity Read ↗

Otx but not Mitf transcription factors are required for zebrafish retinal pigment epithelium development.Semantic proximity Read ↗

Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development.Semantic proximity Read ↗

Mitf-family transcription factor function is required within cranial neural crest cells to promote choroid fissure closureSemantic proximity Read ↗

Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retinaSemantic proximity Read ↗

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