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Article

OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification.

eLife - 29 Apr 2020

Ghinia Tegla Miruna Georgiana, Buenaventura Diego F, Kim Diana Y, Thakurdin Cassandra, Gonzalez Kevin C, Emerson Mark M

Abstract excerpt

During vertebrate retinal development, subsets of progenitor cells generate progeny in a non-stochastic manner, suggesting that these decisions are tightly regulated. However, the gene-regulatory network components that are functionally important in these progenitor cells are largely unknown. Here we identify a functional role for the OTX2 transcription factor in this process. CRISPR/Cas9 gene editing was used to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32347797
DOI: 10.7554/eLife.54279
PMCID: PMC7237216

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