Article
Chx10 functions as a regulator of molecular pathways controlling the regional identity in the primordial retina.
Developmental biology - 1 May 2016
Wang Zi, Yasugi Sadao, Ishii Yasuo
Abstract excerpt
The light-sensitive neural retina (NR) and the retinal pigmented epithelium (RPE) develop from a common primordium, the optic vesicle, raising the question of how they acquire and maintain distinct identities. Here, we demonstrate that sustained misexpression of the Chx10 homeobox gene in the presumptive RPE in chick suppresses accumulation of melanin pigments and promotes ectopic NR-like neural differentiation....
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