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Article

Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development.

Developmental cell - 8 Jan 2018

Moon Kyeong Hwan, Kim Hyoung-Tai, Lee Dahye, Rao Mahesh B, Levine Edward M, Lim Dae-Sik, Kim Jin Woo

Abstract excerpt

The optic neuroepithelial continuum of vertebrate eye develops into three differentially growing compartments: the retina, the ciliary margin (CM), and the retinal pigment epithelium (RPE). Neurofibromin 2 (Nf2) is strongly expressed in slowly expanding RPE and CM compartments, and the loss of mouse Nf2 causes hyperplasia in these compartments, replicating the ocular abnormalities seen in human NF2 patients. The...

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Identifiers

PMID: 29249622
DOI: 10.1016/j.devcel.2017.11.011
PMCID: PMC5760287

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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