Article
Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina
17 Mar 2006
Abstract excerpt
In the Chx10-null ocular retardation (or(J)) mouse, retinal progenitor cell (RPC) proliferation is impaired, and bipolar neurons, a late born cell type, fail to differentiate. It is unclear whether Chx10 is required to maintain proliferation throughout retinogenesis or whether the bipolar cell defect is an indirect effect of growth arrest. We show that Chx10 is dispensable for late-stage RPC proliferation but is...
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