Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vax1/2 genes counteract Mitf-induced respecification of the retinal pigment epithelium.

PloS one - 1 Jan 2013

Ou Jingxing, Bharti Kapil, Nodari Alessandro, Bertuzzi Stefano, Arnheiter Heinz

Abstract excerpt

During vertebrate eye development, the transcription factor MITF acts to promote the development of the retinal pigment epithelium (RPE). In embryos with Mitf mutations, the future RPE hyperproliferates and is respecified as retinal tissue but only in a small portion of the dorsal RPE. Using a series of genetic crosses, we show that this spatial restriction of RPE respecification is brought about by persistent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular Signal-Regulated MAP Kinases
Share to Fibroblast Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Jagged-1 Protein

Share to Microphthalmia-Associated Transcription Factor

Share to Neuropeptides

Share to Receptors, Notch

Share to Retinal Pigment Epithelium

Share to Serrate-Jagged Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23555005
DOI: 10.1371/journal.pone.0059247
PMCID: PMC3598659

Genes

RPE
MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vax1/2 genes counteract Mitf-induced respecification of the retinal pigment epithelium.PMID 23555005Read ↗

Vax2 inactivation in mouse determines alteration of the eye dorsal-ventral axis, misrouting of the optic fibres and eye coloboma.Semantic proximity Read ↗

Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutant.Semantic proximity Read ↗

AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle.Semantic proximity Read ↗

Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity.Semantic proximity Read ↗

Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes.Semantic proximity Read ↗

Patterning the optic neuroepithelium by FGF signaling and Ras activation.Semantic proximity Read ↗

Pax6 induces ectopic eyes in a vertebrate.Semantic proximity Read ↗

Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression.Semantic proximity Read ↗

<i>Vax2</i> regulates retinoic acid distribution and cone opsin expression in the vertebrate eyeSemantic proximity Read ↗

A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis.Semantic proximity Read ↗

nev (cyfip2) is required for retinal lamination and axon guidance in the zebrafish retinotectal system.Semantic proximity Read ↗

Xenopus mutant reveals necessity of rax for specifying the eye field which otherwise forms tissue with telencephalic and diencephalic character.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.