Article
Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation.
Nature genetics - 1 Apr 1996
Burmeister M, Novak J, Liang M Y, Basu S, Ploder L, Hawes N L, Vidgen D, Hoover F, Goldman D, Kalnins V I, Roderick T H, Taylor B A, Hankin M H, McInnes R R
Abstract excerpt
Ocular retardation (or) is a murine eye mutation causing microphthalmia, a thin hypocellular retina and optic nerve aplasia. Here we show that mice carrying the OrJ allele have a premature stop codon in the homeobox of the Chx10 gene, a gene expressed at high levels in uncommitted retinal progenitor cells and mature bipolar cells. No CHX10 protein was detectable in the retinal neuroepithelium of orJ homozygotes....
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