Article
LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Apr 2013
Roy Achira, de Melo Jimmy, Chaturvedi Dhananjay, Thein Thuzar, Cabrera-Socorro Alfredo, Houart Corinne, Meyer Gundela, Blackshaw Seth, Tole Shubha
Abstract excerpt
Eye formation is regulated by a complex network of eye field transcription factors (EFTFs), including LIM-homeodomain gene LHX2. We disrupted LHX2 function at different stages during this process using a conditional knock-out strategy in mice. We find that LHX2 function is required in an ongoing fashion to maintain optic identity across multiple stages, from the formation of the optic vesicle to the...
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