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Article

Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation.

The Journal of biological chemistry - 11 Feb 2005

Zhou Ruifeng, Snyder Peter M

Abstract excerpt

Serum and glucocorticoid-regulated kinase (SGK) plays a key role in the regulation of epithelial Na+ transport. SGK phosphorylates Nedd4-2, an E3 ubiquitin-protein ligase that targets the epithelial Na+ channel (ENaC) for degradation. Phosphorylation increases Na+ transport by reducing Nedd4-2 binding to ENaC, which increases ENaC expression at the cell surface. Thus, SGK expression must be tightly controlled to...

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Identifiers

PMID: 15576372
DOI: 10.1074/jbc.M411053200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation.PMID 15576372Read ↗

Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3.Semantic proximity Read ↗

Nedd4-2 catalyzes ubiquitination and degradation of cell surface ENaC.Semantic proximity Read ↗

Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites.Semantic proximity Read ↗

Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways.Semantic proximity Read ↗

Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition.Semantic proximity Read ↗

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.Semantic proximity Read ↗

A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein.Semantic proximity Read ↗

A regulated NH2-terminal Sgk1 variant with enhanced function is expressed in the collecting duct.Semantic proximity Read ↗

WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination.Semantic proximity Read ↗

Regulation of a third conserved phosphorylation site in SGK1.Semantic proximity Read ↗

Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2.Semantic proximity Read ↗

Regulation of the Na-K-2Cl cotransporter NKCC2 by ubiquitylationSemantic proximity Read ↗

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