Article
Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition.
Pflugers Archiv : European journal of physiology - 1 Jun 2006
Rauh Robert, Dinudom Anuwat, Fotia Andrew B, Paulides Marios, Kumar Sharad, Korbmacher Christoph, Cook David I
Abstract excerpt
The epithelial sodium channel (ENaC) is the major mediator of sodium transport across the apical membranes of the distal nephron, the distal colon, the respiratory tract and the ducts of exocrine glands. It is subject to feedback inhibition by increased intracellular Na+, a regulatory system wherein the ubiquitin protein ligases, Nedd4 and Nedd4-2, bind to conserved PY motifs in the C-termini of ENaC and...
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