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Article

Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2.

The Journal of biological chemistry - 2 Jan 2009

Edinger Robert S, Lebowitz Jonathan, Li Hui, Alzamora Rodrigo, Wang Huamin, Johnson John P, Hallows Kenneth R

Abstract excerpt

We have previously shown that IkappaB kinase-beta (IKKbeta) interacts with the epithelial Na+ channel (ENaC) beta-subunit and enhances ENaC activity by increasing its surface expression in Xenopus oocytes. Here, we show that the IKKbeta-ENaC interaction is physiologically relevant in mouse polarized kidney cortical collecting duct (mpkCCDc14) cells, as RNA interference-mediated knockdown of endogenous IKKbeta in...

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Source

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Identifiers

PMID: 18981174
DOI: 10.1074/jbc.M807358200
PMCID: PMC2610498

Genes

SGK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2.PMID 18981174Read ↗

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