Article
Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites.
The Journal of biological chemistry - 28 Oct 2011
Chandran Sindhu, Li Hui, Dong Wuxing, Krasinska Karolina, Adams Chris, Alexandrova Ludmila, Chien Allis, Hallows Kenneth R, Bhalla Vivek
Abstract excerpt
Regulation of epithelial Na(+) channel (ENaC)-mediated transport in the distal nephron is a critical determinant of blood pressure in humans. Aldosterone via serum and glucocorticoid kinase 1 (SGK1) stimulates ENaC by phosphorylation of the E3 ubiquitin ligase Nedd4-2, which induces interaction with 14-3-3 proteins. However, the mechanisms of SGK1- and 14-3-3-mediated regulation of Nedd4-2 are unclear. There are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.