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Article

A regulated NH2-terminal Sgk1 variant with enhanced function is expressed in the collecting duct.

American journal of physiology. Renal physiology - 1 Dec 2012

Raikwar Nandita S, Liu Kang Z, Thomas Christie P

Abstract excerpt

Sgk1 is a relatively unstable kinase that regulates epithelial Na(+) transport in the distal nephron of the kidney. We identified a 5' variant alternate transcript of human Sgk1 (Sgk1_v3) that is expressed in the connecting tubule and collecting duct, is regulated by aldosterone and insulin, and is predicted to encode an NH(2)-terminal variant Sgk1 isoform, Sgk1_i3. Sgk1_i3 contains a polybasic motif, KKR, in its...

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Identifiers

PMID: 23034940
DOI: 10.1152/ajprenal.00191.2012
PMCID: PMC3532487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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