Article
A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein.
The Journal of biological chemistry - 27 Dec 2013
Andersen Martin Nybo, Krzystanek Katarzyna, Petersen Frederic, Bomholtz Sofia Hammami, Olesen Søren-Peter, Abriel Hugues, Jespersen Thomas, Rasmussen Hanne Borger
Abstract excerpt
Epithelial cell polarization involves several kinase signaling cascades that eventually divide the surface membrane into an apical and a basolateral part. One kinase, which is activated during the polarization process, is phosphoinositide 3-kinase (PI3K). In MDCK cells, the basolateral potassium channel Kv7.1 requires PI3K activity for surface-expression during the polarization process. Here, we demonstrate that...
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