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Article

Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways.

The Journal of biological chemistry - 1 Oct 2010

Zhou Ruifeng, Kabra Rajesh, Olson Diane R, Piper Robert C, Snyder Peter M

Abstract excerpt

Epithelial Na(+) absorption is regulated by Nedd4-2, an E3 ubiquitin ligase that reduces expression of the epithelial Na(+) channel (ENaC) at the cell surface. Defects in this regulation cause Liddle syndrome, an inherited form of hypertension. Previous work found that Nedd4-2 functions through two distinct effects on trafficking, enhancing both ENaC endocytosis and ENaC degradation in lysosomes. To investigate...

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Identifiers

PMID: 20675381
DOI: 10.1074/jbc.M110.150755
PMCID: PMC2945546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways.PMID 20675381Read ↗

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