Article
cAMP-induced desensitization of surface cAMP receptors in Dictyostelium: different second messengers mediate receptor phosphorylation, loss of ligand binding, degradation of receptor, and reduction of receptor mRNA levels.
Molecular biology of the cell - 1 Jun 1992
Van Haastert P J, Wang M, Bominaar A A, Devreotes P N, Schaap P
Abstract excerpt
Surface cAMP receptors on Dictyostelium cells are linked to several second messenger systems and mediate multiple physiological responses, including chemotaxis and differentiation. Activation of the receptor also triggers events which desensitize signal transduction. These events include the foll...
Topics
- Animals
- Cyclic AMP
- Dictyostelium
- Mutation
- Phosphorylation
- RNA, Messenger
- Receptors, Cyclic AMP
- Second Messenger Systems