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Article

Reduction of the fitness burden of quinolone resistance in Pseudomonas aeruginosa.

The Journal of antimicrobial chemotherapy - 1 Jan 2005

Kugelberg Elisabeth, Löfmark Sonja, Wretlind Bengt, Andersson Dan I

Abstract excerpt

OBJECTIVES: Quinolone resistance in the opportunistic pathogen Pseudomonas aeruginosa is commonly caused by mutations that alter the target molecules DNA gyrase/topoisomerase IV, or cause activation of various efflux systems. We have analysed the effect of quinolone resistance caused by DNA gyrase/topoisomerase IV mutations on bacterial fitness. METHODS: Norfloxacin-resistant mutants were isolated and by DNA...

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Identifiers

PMID: 15574475
DOI: 10.1093/jac/dkh505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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