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Article

Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments.

International journal of antimicrobial agents - 1 May 2005

Hopkins Katie L, Davies Robert H, Threlfall E John

Abstract excerpt

Fluoroquinolones are broad-spectrum antimicrobials highly effective for treatment of a variety of clinical and veterinary infections. Their antibacterial activity is due to inhibition of DNA replication. Usually resistance arises spontaneously due to point mutations that result in amino acid substitutions within the topoisomerase subunits GyrA, GyrB, ParC or ParE, decreased expression of outer membrane porins, or...

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Identifiers

PMID: 15848289
DOI: 10.1016/j.ijantimicag.2005.02.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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