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Article

Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coli.

Molecular biology and evolution - 1 May 2017

Huseby Douglas L, Pietsch Franziska, Brandis Gerrit, Garoff Linnéa, Tegehall Angelica, Hughes Diarmaid

Abstract excerpt

Ciprofloxacin is an important antibacterial drug targeting Type II topoisomerases, highly active against Gram-negatives including Escherichia coli. The evolution of resistance to ciprofloxacin in E. coli always requires multiple genetic changes, usually including mutations affecting two different drug target genes, gyrA and parC. Resistant mutants selected in vitro or in vivo can have many different mutations in...

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Identifiers

PMID: 28087782
DOI: 10.1093/molbev/msx052
PMCID: PMC5400412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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