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Article

Interplay between plasmid-mediated and chromosomal-mediated fluoroquinolone resistance and bacterial fitness in Escherichia coli.

The Journal of antimicrobial chemotherapy - 1 Dec 2014

Machuca Jesús, Briales Alejandra, Labrador Gema, Díaz-de-Alba Paula, López-Rojas Rafael, Docobo-Pérez Fernando, Martínez-Martínez Luis, Rodríguez-Baño Jesús, Pachón Maria Eugenia, Pascual Alvaro, Rodríguez-Martínez José-Manuel

Abstract excerpt

OBJECTIVES: The aim of this study was to analyse the interplay among plasmid-mediated qnr genes, alone or in combination with multiple chromosomal-mediated fluoroquinolone (FQ) resistance determinants, susceptibility to FQs and bacterial fitness in an isogenic Escherichia coli collection. METHODS: E. coli ATCC 25922 was used to modify or delete chromosomal genes. qnr genes were cloned into the pBK-CMV vector. The...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25139837
DOI: 10.1093/jac/dku308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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