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Gene-Gene Interactions Dictate Ciprofloxacin Resistance in Pseudomonas aeruginosa and Facilitate Prediction of Resistance Phenotype from Genome Sequence Data.

Antimicrobial agents and chemotherapy - 17 Jun 2021

Rehman Attika, Jeukens Julie, Levesque Roger C, Lamont Iain L

Abstract excerpt

Ciprofloxacin is one of the most widely used antibiotics for treating Pseudomonas aeruginosa infections. However, P. aeruginosa acquires mutations that confer ciprofloxacin resistance, making treatment more difficult. Resistance is multifactorial, with mutations in multiple genes influencing the resistance phenotype. However, the contributions of individual mutations and mutation combinations to the amounts of...

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PMID: 33875431
DOI: 10.1128/AAC.02696-20
PMCID: PMC8218647

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