Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer

1 Dec 2004

Abstract excerpt

Cancer cells are characterized by a generalized disruption of the DNA methylation pattern involving an overall decrease in the level of 5-methylcytosine together with regional hypermethylation of particular CpG islands. The extent of both DNA hypomethylation and hypermethylation in the tumor cell is likely to reflect distinctive biological and clinical features, although no studies have addressed its concurrent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Cancer Screening and Detection
Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15574462
DOI: 10.1093/hmg/ddi028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential DNA hypermethylation and hypomethylation signatures in colorectal cancerPMID 15574462Read ↗

DNA methylation aberrancies delineate clinically distinct subsets of colorectal cancer and provide novel targets for epigenetic therapies.Semantic proximity Read ↗

Genome-scale analysis of aberrant DNA methylation in colorectal cancer.Semantic proximity Read ↗

Aberrant DNA methylation profiles of inherited and sporadic colorectal cancerSemantic proximity Read ↗

Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal CancerSemantic proximity Read ↗

Comparing the DNA hypermethylome with gene mutations in human colorectal cancer.Semantic proximity Read ↗

Accumulation of aberrant DNA methylation during colorectal cancer development.Semantic proximity Read ↗

Methylation and colorectal cancerSemantic proximity Read ↗

The epigenetics of colorectal cancer.Semantic proximity Read ↗

Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features.Semantic proximity Read ↗

Epigenetic changes in colorectal cancer.Semantic proximity Read ↗

Promoter Hypermethylation of Tumour Suppressor Genes as Potential Biomarkers in Colorectal CancerSemantic proximity Read ↗

Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.