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Article

Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics.

European journal of cancer (Oxford, England : 1990) - 1 Jun 2008

Deng Guoren, Kakar Sanjay, Tanaka Hirofumi, Matsuzaki Koji, Miura Soichiro, Sleisenger Marvin H, Kim Young S

Abstract excerpt

INTRODUCTION: Accumulation of genetic and epigenetic alterations contribute to malignant transformation of normal colonic mucosa to cancer. However, the frequency and the pattern of these alterations in proximal and distal colon cancers have not been examined in detail. METHODS: In this study, we examined methylation frequencies and patterns using 14 marker genes in 31 proximal and 43 distal colorectal cancers....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18486467
DOI: 10.1016/j.ejca.2008.03.014

Genes

BRAF
KRAS
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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