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Article

Epigenetic changes in colorectal cancer.

Cancer metastasis reviews - 1 Jan 2000

Kondo Yutaka, Issa Jean-Pierre J

Abstract excerpt

Epigenetic silencing is now recognized as a 'third pathway' in Knudson's model of tumor-suppressor gene inactivation in cancer and can affect gene function without genetic changes. DNA methylation within gene promoters and alterations in histone modifications appear to be primary mediators of epigenetic inheritance in cancer cells. For selected genes, epigenetic changes are tightly related to neoplastic...

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Identifiers

PMID: 15000147
DOI: 10.1023/a:1025806911782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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